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KMID : 0359920140330010052
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Korean Journal of Nephrology
2014 Volume.33 No. 1 p.52 ~ p.57
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Serum calcium and phosphorus levels in patients undergoing maintenance hemodialysis: A multicentre study in Korea
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Kim Gheun-Ho
Choi Bum-Soon
Cha Dae-Ryong
Chee Dong-Hyun
Hwang Eun-Ah
Kim Hyung-Wook
Chang Jae-Hyun
Kim Joong-Kyung
Noh Jung-Woo
Joo Kwon-Wook
Lee Sang-Cheol
Han Sang-Woong
Kim Se-Joong
Kim Soo-Wan
Shin Sug-Kyun
Park Won-Do
Kim Won
Huh Woo-Seong
Kwon Young-Joo
Kang Young-Sun
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Abstract
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Background: In many countries, nephrologists follow clinical practice guidelines for mineral bone disorders to control secondary hyperparathyroidism (SHPT) associated with abnormal serum calcium (Ca) and phosphorus (P) levels in patients undergoing maintenance hemodialysis (MHD). The Kidney Disease Outcomes Quality Initiative (KDOQI) Guidelines have long been used in Korea, and this study was undertaken to investigate the current status of serum Ca and P control in MHD patients.
Methods: Data were collected from a total of 1,018 patients undergoing MHD without intercurrent illness, in 17 hemodialysiscenters throughout the country. Serum levels of Ca, P, and intact parathyroid hormone (iPTH) were measured over 1 year, and the average values were retrospectively analyzed.
Results: Serum levels of Ca, P, and the CaP product were 9.170.7mg/dL, 5.37 1.4mg/dL, and 48.0713.6mg2/dL2, respectively. However, the percentages of patients with Ca, P, and Ca P product levels within the KDOQI guideline ranges were 58.7%, 51.0%, and 70.7%, respectively. Of the 1,018 patients, 270 (26.5%) had iPTH 4300pg/mL (uncontrolled SHPT), whereas 435 patients (42.7%) showed iPTH o150pg/mL. Patients with uncontrolled SHPT had signi?cantly higher values of serum Ca, P, and CaP product than those with iPTH r300pg/mL.
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KEYWORD
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Calcium, Hemodialysis, Intact parathyroidhormone, Phosphorus, Secondary hyperparathyroidism
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